Ti-Nb β alloys are a promising alternative as an implant material due to their good properties and low Young’s modulus compared to other Ti-alloys currently employed as biomaterials. In this study three materials of the Ti-Nb and Ti-Nb-Fe systems were produced by powder metallurgy techniques starting from TiH2 (TH) powder. Several sintering cycles were employed to evaluate the H2 elimination and the effect of sintering temperature on densification and fraction of β-Ti phase. Also the influence of alloying element size using two kinds of Fe powder was evaluated. The highest loss of H2 was achieved decreasing heating rate at the temperature range of hydride decomposition. SEM images and XRD results show mainly a β-Ti phase for TH40Nb and TH5Fe25Nb samples. The TH12Nb sample shows (α+β) microstructure. Fe addition with smaller particle size seems to improve the diffusion of Nb into Ti what promotes a higher β-phase fraction and sample homogeneity.