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Loading and Distribution of Ag Nanoparticles in Porous TiO2 Antibacterial Layers

  • : Necula, B S1
  • : 1Delft University of Technology
  • : PDF Download
  • : 2012

Abstract

Implant associated infections may be prevented by providing antibacterial properties to the implant surface prior to implantation. Using a plasma electrolytic oxidation process, porous TiO2 layers bearing silver nanoparticles were produced on a Ti6Al7Nb biomedical alloy. The aim of this study was to determine the loading and distribution of Ag nanoparticles into the porous oxide layers and assess their in vitro antibacterial capability. Prior to the layer synthesis, particle size distribution and surface charge of as-received Ag nanoparticles were assessed. The distribution of Ag nanoparticles into the porous TiO2 layers was investigated using transmission electron microscopy and scanning electron microscopy techniques. Bactericidal activity of porous layers bearing Ag particles was tested against one of the most virulent pathogen responsible for implant associated infections, i.e. methicillin resistant Staphylococcus aureus. The results suggested good distribution of the Ag nanoparticles in the TiO2 matrix and an excellent in vitro bactericidal activity.
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