Titanium and some of its alloys, especially Ti-6Al-4V have gained considerable interest due to excellent mechanical properties, such as high strength and stiffness combined with low density, as well as good corrosion resistance. Since conventional manufacturing processes are quite costly metal injection moulding (MIM) seems to be a competitive alternative for small to medium sized titanium parts. However, for most applications the mechanical properties of MIM parts, especially the fatigue properties, are still a limiting factor. To gain further information on the high cycle fatigue (HCF) behaviour, CP-Ti and Ti-6Al-4V specimens were produced in-house by MIM. Rotating bending tests were carried out and compared with wrought material as a reference. In order to investigate the influence of microstructure and porosity different sintering strategies were applied. Fatigue properties were found to be lower in the MIM case by typically 50 %. Possibilities for improved microstructures and processing conditions will be discussed.