The dimensional accuracy of powder Hot Isostatic Pressed (HIP) components is determined by many factors, such as the shape and size of the capsule, the average relative density, density distribution of the powder prior to HIP, as well as by the process parameters pressure and temperature. The results of previous studies showed that the initial powder density distribution inside the capsule depends strongly on the filling procedure and the pre-compaction process prior to HIP. In this work, the initial powder density distribution inside a capsule is analyzed quantitatively and compared for different filling techniques and pre-compaction steps. The powder density distribution is determined by Image Analysis (IA) and used as initial condition for the numerical simulation of the powder consolidation during HIP by Finite Element Analysis (FEA). The final shapes of the capsules produced by HIP are compared to simulation results. The paper elucidates the sensitivity of the initial powder density distribution to the consolidation behavior during HIP and the final component shape. The influence of initial powder distribution on the final shape of hot isostatically pressed components is studied via simulation and experimental works. The results explain one reason for the non-uniform shrinkage of components produced by HIP.