A metal-ceramic bonding by powder injection molding (PIM) was studied. Stainless steel and zirconia powders were used for bonding materials. A wax-polymer binder system composed of paraffin wax(PW), polypropylene(PP), polyethylene(PE) and stearic acid(SA) was used. In injection molding process, insert-injection molding was used to produce mixed layer. The processing conditions for mixing, injection molding, debinding, and sintering were optimized to avoid defects in final sintered part. As a result, the metal-mixed and ceramic-mixed bonded parts were fabricated by PIM with optimized processing conditions. The microstructures and chemical compositions at the bonding interface were confirmed by scanning electron microscope (SEM) and energy dispersive x-ray spectroscopy (EDS).