The aim of this work focuses on the evaluation of modified Ti surfaces produced by powder metallurgy. These new designed materials are processed by deposition and diffusion of a stable aqueous suspension prepared in one case from micro-sized Nb powder (Ti β-stabilizer element); and in another case, from Nb plus the addition of ammonium chloride, NH4Cl, (thermo-reactive diffusion process). Different design parameters such as: diffuser element (Nb or Mo), state of the Ti substrate (green or sintered) and the treatment process (diffusion or thermo-reactive diffusion) lead to all the surface-modified materials, GreenTi-Nb, SintTi-Nb and Ti-NbNH4Cl, GreenTi-Mo, SintTi-Mo and Ti-MoNH4Cl. They present a gradient in composition and microstructure (β – α/β – α phases) resulting in an improvement in some of their mechanical properties: (1) higher micro-hardness in all the modified materials, and (2) lower elastic modulus (more similar to that of the human bone) in those without NH4Cl.