This paper presents a numerical study on the fatigue crack growth of WC-Co hardmetal at the mesoscale. The earlier adopted model has been extended using the Chaboche plasticity model, and the quality of description on cyclic kinematic hardening for ductile binder is more adequate with this superimposition. Another advancement is the introduction of WC’s orthotropic nature. It offers an investigation of hardmetals fatigue dependency on its microstructure from the crystallographic point of view, which is missing in earlier trials. The development is integrated into a damage model and implemented as a user subroutine in commercial finite element solver Abaqus/Standard to capture hardmetals progressive damage behavior. Using the established methodology, a series of numerical studies is performed on two artificial representative volume element (RVE) models subjected to cyclic loading with different stress amplitude, aiming at investigating the fatigue micro-crack growth in hardmetals and interpreting results with consideration of the crystalline structure.