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Particularities Of Bioresorbable Polymer Core Shell/ Iron Oxide Magnetic 2D And 3D Nanocomposites Synthesized Via SLS/M Process

  • : Igor Shishkovsky1, Larisa Volova2, Stanislav Volchkov2
  • : 1Lebedev Physical Institute of Russian Academy of Sciences Samara branch, 2Samara State Medical University
  • : PDF Download
  • : 2017

Abstract

The selective laser sintering/melting (SLS/M) process was used for fabrication and characterization of polymer 3D and 2D nanocomposite based on nanooxides of FexOy type with bioresorbable polycaprolactone (PCL) powder and manufacturing of porous tissue engineering scaffolds. A principal feasibility for fabrication of functionally graded three dimensional (3D) parts with nano iron oxide particles and structural ordering were demonstrated and corresponding laser optimal regimes were determined. Results of microstructural evaluation of nano ferric oxide samples were conducted using SEM equipped with EDX microanalysis. Estimation of material loss (biodegradation) was carried out through weighting and Raman spectroscopy of the materials before and after the medical tests. The stem cellular morphology, proliferative MMSC activity and adhesion of the 2D and 3D nano magnetic composite matrices were the subjects of comparison. Medical potential of the SLS/M-fabricated superparamagnetic nano iron oxides for tissue engineering scaffolds and cell targeting systems were discussed.

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