One of the major trends in cemented carbide industry is to find a suitable substitution of Co as metallic binder phase. Ni-based binders alloyed with Si Mo and/or Cr are interesting options. Within this context fracture behavior and fatigue life of two WC-NiMo cemented carbides with different grain size were investigated. Hardness flexural strength fracture toughness and fatigue life were evaluated. Results in this investigation show that hardness flexural strength and fracture toughness are within the range of those reported for other WC-based systems with similar binder mean free path. Regarding fatigue it was found that influence of carbide grain size is more pronounced under cyclic loads than under monotonic ones. Fatigue sensitivity assessed for NiMo-based grades is within the lower limit of values reported for Co- and CoNi-based cemented carbides allowing to speculate on an improved fatigue response associated with binder chemical nature and/or coarser microstructures.